Dental Reconstructive Technologies/Regenerative Dentistry

An ideal goal of oral-craniofacial dental reconstructive therapy is to establish treatment modalities that predictably restore functional tissues. One major area of focus has been in the area of dental materials with marked improvements in the design of materials used to restore teeth/periodontium/bone lost as a consequence of disease or disorders.

More than 85% of the global population requires repair or replacement of a craniofacial structure. These defects range from simple tooth decay to radical oncologic craniofacial resection.
Advanced technologies by using tissues repair cells and growth factors represent a very interesting field for craniofacial tissues regeneration. They represent a potential key component in autologos graft for craniofacial tissues regeneration. Recent progress in the studies of molecular basis of tooth development, adult stem cell biology, and regeneration are providing fundamental knowledge for the utilization of human craniofacial tissues regeneration.

Replacing missing bone or adding mass to existing bone is often essential to the success of a dental implant. An implant needs a critical mass of bone surrounding it in order to bind (oseointgrate) to it and deliver sufficient strength and stability. In case of low bone mass in the intended implants location, a bone graft must be applied in order to maintain this critical bone mass.

 

Our Center has introduced a new technology "Autologous bone marrow derived mononuclear cells combined with Bone Replacement Materials (Xenografts) in Advanced Maxillary and Mandibular Atrophy" - a safe effective method for replacing missing bone and adding mass to existing bone for dental implants.

Advantages of Bone Marrow Mononuclear Cells combined with Xenograft:

- Promotes revascularization and clot stabilization, due to its interconnecting macro and micropores;

- Effective space maintenance, and when integrated, provides mechanical strength and stiffness due to retention of the natural mineral content;

- Optimal integration with patient's own bone aided by a chemical composition analogous to human bone with fewer hydroxyl and more carbonate groups than most synthetic materials;

- Bone Marrow Mononuclear Cells + Xenograft is integrated during the natural remodelling process of the human bone and slowly resorbed due to small crystallite size comparable to human bone;

- Bone Marrow Mononuclear Cells + Xenograft prevents newly formed bone from rapid resorption that leads to a long-term preservation of the bone volume.

Process of natural bone regeneration by bone marrow derived mononuclear cells combined with Xenograft

1. Clot stabilization facilitated by Bone Marrow Mononuclear Cells + Xenograft interconnecting macro and micropores. 2. Revascularization, migration of osteoblasts (purple) and in-growth of woven bone (yellow) is enhanced by Bone Marrow Mononuclear Cells + Xenograft scaffolding. 3. Lamellar bone and Bone Marrow Mononuclear Cells + Xenograft are successfully integrated after approximately six months. Xenograft is included in the natural physiologic remodeling process (osteoclasts - Blue).

BENIFITS: MINIMAL INVASIVE -  FASTER RECOVERY - EXTREMELY ACCURATE

Our experience with autologous bone marrow derived mononuclear cells combined with Xenografts for augmentation of the extremely atrophied maxilla and mandible is presented:

 

 

A. Before. B, C, D. Healing period in 5 months. Complete osteoconductive integration of the bone subtitute material

in the mature bone is achieved.

Healing period in 7 months.